General Information
-
DRAMP ID
- DRAMP02393
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Peptide Name
- HFIAP-1 (HFIAP-2; hagfishes, chordates, animals)
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Source
- Myxine glutinosa (Atlantic hagfish)
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Family
- Not found
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Gene
- Not found
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Sequence
- GFFKKAWRKVKHAGRRVLDTAKGVGRHYVNNWLNRYRZ
-
Sequence Length
- 38
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UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-positive bacteria: Propionibacterium acnes ATCC 11827/33179 (MIC=2 µg/ml), Staphylococcus epidermidi (MIC=2-4 µg/ml), Streptococcus pyogenes (MIC=4 µg/ml), Enterococcus faecium (MIC=4-8 µg/ml), Staphylococcus aureus ATCC 29213 (MIC=8 µg/ml), Clostridium perfringens ATCC 9081/13124 (MIC=4-32 µg/ml), Enterococcus faecalis (MIC=32 µg/ml);
- Gram-negative bacteria: Bacteroides spp. ATCC 29771/43935/12290 (MIC=0.5-4 µg/ml), Shigella sonnei (MIC=2-4 µg/ml), Xanthomonas maltophilia (MIC=2-8 µg/ml), Salmonella Group B (MIC=4-8 µg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 µg/ml), Acinetobacter baumannii (MIC=8-16 µg/ml), Escherichia coli ATCC 25922 (MIC=8 µg/ml), Enterobacter aerogenes (MIC=8-16 µg/ml), Enterobacter cloacae (MIC=8-16 µg/ml), Klebsiella pneumoniae (MIC=8-16 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02393.
Physicochemical Information
-
Formula
- C205H317N69O45
Absent Amino Acids
- CEIMPQS
Common Amino Acids
- R
Mass
- 4614.97
PI
- 11.74
Basic Residues
- 13
Acidic Residues
- 1
Hydrophobic Residues
- 13
Net Charge
- +12
-
Boman Index
- -112.27
Hydrophobicity
- -1.005
Aliphatic Index
- 58.95
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 13980
Absorbance 280nm
- 377.84
Polar Residues
- 10
DRAMP02393
Comments Information
Function
- Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species.
Sequence similarity
- Sequences for HFIAP-1 and -2 are identical, but HFIAP-2 is brominated only at residue 7; they differ from MgCath37 by conservative replacements.
Literature Information
- ·Literature 1
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Title
- Hagfish intestinal antimicrobial peptides are ancient cathelicidins.
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Pubmed ID
- 15019197
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Reference
- Peptides. 2003 Nov;24(11):1655-1667.
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Author
- Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M.