General Information

    • DRAMP ID

    • DRAMP02399

    • Peptide Name

    • Antimicrobial peptide EP-20 (EP-20)

    • Source

    • Xenorhabdus budapestensis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • EGPVGLADPDGPASAPLGAP

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Phytophthora capsici (EC50=3.14 µg/ml), Verticillium dahlia (CD=19.32±1.31 mm), Fusarium graminearum (CD=12.45±1.6 mm), Fusarium oxysporum (CD=21.29±1.1 mm).
      • NOTE: CD = Colony diameter.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02399 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02399.

Physicochemical Information

    • Formula

    • C78H122N20O28

    • Absent Amino Acids

    • CFHIKMNQRTWY

    • Common Amino Acids

    • P

    • Mass

    • 1787.94

    • PI

    • 3.49

    • Basic Residues

    • 0

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 7

    • Net Charge

    • -3

    • Boman Index

    • -2.77

    • Hydrophobicity

    • -0.095

    • Aliphatic Index

    • 73.5

    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP02399

DRAMP02399 chydropathy plot

Comments Information

    • Function

    • EP-20 showes high inhibition against P. capsici but lower antibacterial activity.

Literature Information

  • ·Literature 1

    • Title

    • Two novel antimicrobial peptides purified from the symbiotic bacteria Xenorhabdus budapestensis NMC-10.

    • Reference

    • Peptides. 2012 Jun;35(2):253-260.

    • Author

    • Xiao Y, Meng F, Qiu D, Yang X.