General Information

    • DRAMP ID

    • DRAMP02405

    • Peptide Name

    • Antifungal protein 1 (Pf-AFP1; Plants)

    • Source

    • Passiflora edulis (Passion fruit)

    • Family

    • Belongs to the 2S seed storage albumins family

    • Gene

    • Not found

    • Sequence

    • QSERFEQQMQGQDFSHDERFLSQAA

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Trichoderma harzianum (IC50=32 µg/ml), Fusarium oxysporum (IC50=34 µg/ml), Aspergillus fumigatus (IC50=40 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02405 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02405.

Physicochemical Information

    • Formula

    • C126H187N39O45S

    • Absent Amino Acids

    • CIKNPTVWY

    • Common Amino Acids

    • Q

    • Mass

    • 3000.17

    • PI

    • 4.5

    • Basic Residues

    • 3

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -2

    • Boman Index

    • -95.04

    • Hydrophobicity

    • -1.432

    • Aliphatic Index

    • 23.6

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02405

DRAMP02405 chydropathy plot

Comments Information

    • Function

    • Function

    • Tissue specificity

    • Expressed in seed (at protein level). Not detected in pulp, stems and leaves.

    • Developmental stage

    • Expressed in dormant seed.

Literature Information

  • ·Literature 1

    • Title

    • An antifungal peptide from passion fruit (Passiflora edulis) seeds with similarities to 2S albumin proteins.

    • Reference

    • Biochim Biophys Acta. 2006 Jun;1764(6):1141-6.

    • Author

    • Pelegrini PB, Noronha EF, Muniz MA, Vasconcelos IM, Chiarello MD, Oliveira JT, Franco OL.