• • DRAMP ID

  • DRAMP02421

• • Peptide Name

  • Hlgut-defensin (H. longicornis midgut defensin; Ticks, Arthropods, animals)

• • Source

  • Haemaphysalis longicornis (Bush tick)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • ACHAHCQSVGRRGGYCGNFRMTCYCY

• • Sequence Length

  • 26

• • UniProt Entry

  • A4GUC3

• • Protein Existence

  • Predicted

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-positive bacterium: Staphylococcus aureus (MIC=5-25 mg/mL);
    • Gram-negative bacterium: Escherichia coli (MIC=10-25 mg/mL).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP02421.

DRAMP02421

• • Function

  • Both Hlgut-defensin and Hlsal-defensin sequences have antibactrrial activity against a variety of Gram-positive and Gram-negative bacteria.

• • Induction

  • By a lipopolysaccharide (LPS) injection.

• ·Literature 1

• • Title

  • Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis.

• • Pubmed ID

  • 17521774

• • Reference

  • Peptides. 2007 Jun;28(6):1304-1310.

• • Author

  • Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K.