General Information

    • DRAMP ID

    • DRAMP02422

    • Peptide Name

    • Hlsal-defensin (H. longicornis salivary gland defensin; Ticks, Arthropods, animals)

    • Source

    • Haemaphysalis longicornis (Bush tick)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • NCIQQCVSKGAQGGYCTNEKCTCY

    • Sequence Length

    • 24

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=5-25 mg/mL);
      • Gram-negative bacterium: Escherichia coli (MIC=10-25 mg/mL).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02422 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02422.

Physicochemical Information

    • Formula

    • C104H165N31O37S5

    • Absent Amino Acids

    • DFHLMPRW

    • Common Amino Acids

    • C

    • Mass

    • 2601.94

    • PI

    • 7.81

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +1

    • Boman Index

    • -36.64

    • Hydrophobicity

    • -0.492

    • Aliphatic Index

    • 32.5

    • Half Life

      • Mammalian:1.4 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 3230

    • Absorbance 280nm

    • 140.43

    • Polar Residues

    • 15

DRAMP02422

DRAMP02422 chydropathy plot

Comments Information

    • Function

    • Both Hlgut-defensin and Hlsal-defensin sequences have antibactrrial activity against a variety of Gram-positive and Gram-negative bacteria.

    • Induction

    • By a lipopolysaccharide (LPS) injection.

Literature Information

  • ·Literature 1

    • Title

    • Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis.

    • Reference

    • Peptides. 2007 Jun;28(6):1304-1310.

    • Author

    • Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K.