General Information
-
DRAMP ID
- DRAMP02437
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Peptide Name
- Papillosin
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Source
- Halocynthia papillosa (Red sea-squirt)
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Family
- Not found
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Gene
- Not found
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Sequence
- GFWKKVGSAAWGGVKAAAKGAAVGGLNALAKHIQ
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Sequence Length
- 34
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UniProt Entry
- P86416
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.19085906]Gram-positive bacteria (Native, Synthetic): Micrococcus luteus A270 (MBC=0.13-0.25, 0.19-0.39 µM), Aerococcus viridans 54.145 T (MBC=ND, 0.19-0.39 µM), Bacillus megaterium 66.20 T (MBC=ND, 0.05-0.10 µM), Staphylococcus aureus 65.8 T (MBC=0.5-1.00, 1.56-3.13 µM), Enterococcus faecalis 103015 T (MBC=ND, 0.78-1.56 µM);
- Gram-negative bacteria (Native, Synthetic): Enterobacter aerogenes 30.86 T (MBC=ND, 0.78-1.56 µM), Pseudomonas aeruginosa 100720 T (MBC=ND, 3.13-6.25 µM), Salmonella thyphimurium 60.62 T (MBC=ND, 0.78-1.56 µM), Klebsiella pneumoniae 82.91 T (MBC=ND, 0.39-0.78 µM), Escherichia coli (MBC=0.25-0.50, 0.78-1.56 µM)
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Hemolytic Activity
-
- [Ref.19085906]0% hemolytic activity at 50 μM against sheep erythrocytes
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02437.
Physicochemical Information
-
Formula
- C153H243N45O38
Absent Amino Acids
- CDEMPRTY
Common Amino Acids
- A
Mass
- 3320.89
PI
- 10.6
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 18
Net Charge
- +6
-
Boman Index
- 9.4
Hydrophobicity
- 0.253
Aliphatic Index
- 86.47
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 333.33
Polar Residues
- 9
DRAMP02437
Comments Information
Function
- Has strong antibacterial activity against the Gram-positive bacteria M. luteus, S. aureus, B. megaterium, A. viridans and E. faecalis, and against the Gram-negative bacteria K. pneumoniae, E. coli DH5alpha, S. typhimurium, P. aeruginosa and E. aerogenes. Lacks hemolytic activity against sheep erythrocytes.
Literature Information
- ·Literature 1
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Title
- Halocyntin and papillosin, two new antimicrobial peptides isolated from hemocytes of the solitary tunicate, Halocynthia papillosa.
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Pubmed ID
- 19085906
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Reference
- J Pept Sci. 2009 Jan;15(1):48-55.
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Author
- Galinier R, Roger E, Sautiere PE, Aumelas A, Banaigs B, Mitta G.