• • DRAMP ID

  • DRAMP02446

• • Peptide Name

  • Antimicrobial protein 1 (Antimicrobial protein AN5-1)

• • Source

  • Paenibacillus alvei (Bacillus alvei)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • YSKSLPLSVLNP

• • Sequence Length

  • 12

• • UniProt Entry

  • B3EWQ6

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-positive bacteria: Lactobacillus plantarum strain ATCC 8014 (MIC=32 µg/ml), Lactococcus lactis ATCC 11454 (MIC>128 µg/ml), Bacillus cereus strain ATCC 14579 (MIC=64 µg/ml), Staphylococcus aureus (MIC=64 µg/ml), Bacillus subtilis (MIC=32 µg/ml), Bacillus anthracis (MIC=128 µg/ml) and Bacillus licheniformis (MIC>128 µg/ml), Bacillus flexus (MIC=32 µg/ml);
    • Gram-negative bacteria: Escherichia coli strain ATCC 13076 (MIC=8 µg/ml), Salmonella enteritidis ATCC 13076 (MIC=4 µg/ml), Enterobacter spp. (MIC=16 µg/ml), Serratia marcescens (MIC=32 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP02446_predicted_structure.pdb to download.

DRAMP02446

• • Function

  • Has a broad inhibitory spectrum against both Gram-positive and -negative bacterial strains.

• • Miscellaneous

  • A synthetic peptide has no antibacterial activity against S. agalactiae ATCC 12386, S. epidermidis, P. aeruginosa and methicillin-resistant S. aureus (MRSA).

• • Biophysicochemical properties

  • pH dependence (Active between pH 2 and 12); Temperature dependence (Active between 37 and 90 degrees Celsius. Activity is reduced at 100 degrees Celsius and absent at 110 degrees Celsius. Activity is unaffected by storage at -20 degrees Celsius).

• ·Literature 1

• • Title

  • Detection of secreted antimicrobial peptides isolated from cell-free culture supernatant of Paenibacillus alvei AN5.

• • Pubmed ID

  • 23508455

• • Reference

  • J Ind Microbiol Biotechnol. 2013 Jun;40(6):571-579.

• • Author

  • Alkotaini B, Anuar N, Kadhum AA, Sani AA.