• DRAMP ID

    • DRAMP02458
    • Peptide Name

    • L-amino-acid oxidase (BiLAO; LAAO; LAO; snakes, reptils, animals)
    • Source

    • Bothrops insularis (Golden lancehead) (Queimada jararaca)
    • Family

    • Belongs to the flavin monoamine oxidase family (FIG1 subfamily)
    • Gene

    • Unknown
    • Sequence

    • ADDKNPLEECFREDDYEGFLEIAKNGLSTTSNPKRVVIVGAGMSGLAAY
    • Sequence Length

    • 49
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antiparasitic, Antimicrobial
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP02458 helical wheel diagram
    • Formula

    • C230H361N61O78S2
    • Absent Amino Acids

    • HQW
    • Common Amino Acids

    • AEG
    • Mass

    • 6149.24
    • PI

    • 4.15
    • Basic Residues

    • 5
    • Acidic Residues

    • 9
    • Hydrophobic Residues

    • 16
    • Boman Index

    • -85.98
    • Hydrophobicity

    • -37.76
    • Aliphatic Index

    • 75.71
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 2980
    • Absorbance 280nm

    • 62.08
    • Polar Residues

    • 16

DRAMP02458

DRAMP02458 chydropathy plot
    • Function

    • Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). In addition, this protein induces apoptosis and necrosis and has inhibitory effects on rat kidney Function
    • Tissue specificity

    • Expressed by the venom gland.
  • Literature 1
    • Reference

    • Toxicon. 2008 Feb;51(2):199-207.
    • Author

    • Braga MD, Martins AM, Amora DN, de Menezes DB, Toyama MH, Toyama DO, Marangoni S, Alves CD, Barbosa PS, de Sousa Alves R, Fonteles MC, Monteiro HS.
    • Title

    • Purification and biological effects of L-amino acid oxidase isolated from Bothrops insularis venom.