General Information
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- No secondary structure
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Structure Description
- Not found
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Helical Wheel Diagram
- 1E9W-> 
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Predicted Structure
- There is no predicted structure for DRAMP02471.
Physicochemical Information
-
Formula
- C60H105N17O26S5
Absent Amino Acids
- DEFGHKLMNPQRVWY
Common Amino Acids
- CS
Mass
- 1640.89
PI
- 5.49
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- 0
-
Boman Index
- -4.85
Hydrophobicity
- 1.118
Aliphatic Index
- 57.65
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 250
Absorbance 280nm
- 15.63
Polar Residues
- 13
DRAMP02471
Comments Information
Function
- Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).
PTM
- Maturation of thiazole and oxazole containing antibiotics involves the enzymic condensation of a Cys, Ser or Thr with the alpha-carbonyl of the preceding amino acid to form a thioether or ether bond, then dehydration to form a double bond with the alpha-amino nitrogen. Thiazoline or oxazoline ring are dehydrogenated to form thiazole or oxazole rings. Maturation of pyridinyl containing antibiotics involves the cross-linking of a Ser and a Cys-Ser pair usually separated by 7 or 8 residues along the peptide chain. The Ser residues are dehydrated to didehydroalanines, then bonded between their beta carbons. The alpha carbonyl of the Cys condenses with alpha carbon of the first Ser to form a pyridinyl ring. The ring may be multiply dehydrogenated to form a pyridine ring with loss of the amino nitrogen of the first Ser.
Pharmaceutical use
- Available under the names Animax (Dechra) and Panolog (Fort Dodge), that combine thiostrepton with nystatin (antifungal), neomycin (antibiotic) and triamcinolone (corticosteroid). Used to treat cat and dog skin and ear disorders caused by
Literature Information
- ·Literature 1
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Title
- Thiostrepton, a new antibiotic. I. In vitro studies.
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Pubmed ID
- 13355325
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Reference
- Antibiot Annu. 1955-1956;3:554-559.
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Author
- DONOVICK R, PAGANO JF, STOUT HA, WEINSTEIN MJ.
- ·Literature 2
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Title
- Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur.
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Pubmed ID
- 11320328
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Reference
- Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):755-758.
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Author
- Bond CS, Shaw MP, Alphey MS, Hunter WN.