General Information
-
DRAMP ID
- DRAMP02474
-
Peptide Name
- cathelicidin-BF15 (Snakes, reptiles, animals)
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Source
- Bungarus fasciatus (Banded krait)
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Family
- Not found
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Gene
- Not found
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Sequence
- KFFRKLKKSVKKRAK
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Sequence Length
- 15
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UniProt Entry
- B6D434
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=4.7 µg/ml), P. aeruginosa IS/DR (MIC=37.5 µg/ml), P. aeruginosa 08031205 IS/DR (MIC=18.7 µg/ml), P. aeruginosa 08031014 IS/DR (MIC=75 µg/ml), Escherichia coli ATCC25922 (MIC=18.7 µg/ml), E. coli 08A852 IS/DR (MIC=18.7 µg/ml), E. coli 08A866 IS/DR (MIC=18.7 µg/ml), E. coli 08031017 IS/DR (MIC=37.5 µg/ml), E. coli 08040722 IS/DR (MIC=9.4 µg/ml), K. pneumoniae 08040202 IS/DR (MIC=75 µg/ml), Salmonella Typhi IS/DR (MIC=1.2 µg/ml), Saccharibacillus kuerlensis (MIC=4.7 µg/ml).
- Gram-positive bacteria: Bacillus subtilis (MIC=75 µg/ml), Staphylococcus aureus ATCC2592 (MIC=75 µg/ml), S. aureus 08A875 IS/DR (MIC=75 µg/ml), S. aureus 08031002 IS/DR (MIC>100 µg/ml).
- Fungi: Candida albicans ATCC2002 (MIC=18.7 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP02474_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C89H158N28O17
Absent Amino Acids
- CDEGHIMNPQTWY
Common Amino Acids
- K
Mass
- 1892.41
PI
- 12.05
Basic Residues
- 9
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +9
-
Boman Index
- -55.36
Hydrophobicity
- -1.447
Aliphatic Index
- 52
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP02474
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics.
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Pubmed ID
- 18795096
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Reference
- PLoS One. 2008 Sep 16;3(9):e3217.
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Author
- Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R.