General Information
-
DRAMP ID
- DRAMP02476
-
Peptide Name
- Waprin-Phi3 (Snakes, reptiles, animals)
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Source
- Philodryas olfersii (Green snake)
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Family
- Belongs to the snake waprin family
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Gene
- Not found
-
Sequence
- KTTKQLRLPKVKPGECPKVKIPPDYPCNQYCVWDFDCEGNKKCCPVGCAKECFPPGPL
-
Sequence Length
- 58
-
UniProt Entry
- A7X4M7
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Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02476.
Physicochemical Information
-
Formula
- C289H453N75O79S8
Absent Amino Acids
- HMS
Common Amino Acids
- PK
Mass
- 6498.71
PI
- 8.67
Basic Residues
- 10
Acidic Residues
- 6
Hydrophobic Residues
- 12
Net Charge
- +4
-
Boman Index
- -81.3
Hydrophobicity
- -0.638
Aliphatic Index
- 48.62
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 8980
Absorbance 280nm
- 157.54
Polar Residues
- 18
DRAMP02476
Comments Information
PTM
- four disulfide bonds
Damages membranes of susceptible bacteria.
Literature Information
- ·Literature 1
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Title
- Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia).
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Pubmed ID
- 17855442
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Reference
- Mol Cell Proteomics. 2008 Feb;7(2):215-246.
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Author
- Fry BG, Scheib H, van der Weerd L, Young B, McNaughtan J, Ramjan SF, Vidal N, Poelmann RE, Norman JA.