General Information
-
DRAMP ID
- DRAMP02477
-
Peptide Name
- Waprin-Phi2 (Snakes, reptiles, animals)
-
Source
- Philodryas olfersii (Green snake)
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Family
- Belongs to the snake waprin family
-
Gene
- Not found
-
Sequence
- EQEKPGSCPNVDMPIPPLGLCKTTCSKDSDCSETKKCCKNGCGFMTCTTARP
-
Sequence Length
- 52
-
UniProt Entry
- A7X4K7
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02477.
Physicochemical Information
-
Formula
- C225H372N64O78S10
Absent Amino Acids
- HWY
Common Amino Acids
- C
Mass
- 5542.41
PI
- 7.76
Basic Residues
- 7
Acidic Residues
- 6
Hydrophobic Residues
- 6
Net Charge
- +1
-
Boman Index
- -100.36
Hydrophobicity
- -0.64
Aliphatic Index
- 30
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 500
Absorbance 280nm
- 9.8
Polar Residues
- 24
DRAMP02477
Comments Information
PTM
- four disulfide bonds 8-38; 21-42; 25-37; 31-47.
Damages membranes of susceptible bacteria.
Literature Information
- ·Literature 1
-
Title
- Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia).
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Pubmed ID
- 17855442
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Reference
- Mol Cell Proteomics. 2008 Feb;7(2):215-246.
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Author
- Fry BG, Scheib H, van der Weerd L, Young B, McNaughtan J, Ramjan SF, Vidal N, Poelmann RE, Norman JA.