General Information
-
DRAMP ID
- DRAMP02485
-
Peptide Name
- Waprin-Rha1 (Snakes, reptiles, animals)
-
Source
- Rhabdophis tigrinus tigrinus (Tiger keelback snake)
-
Family
- Belongs to the snake waprin family
-
Gene
- Not found
-
Sequence
- QDGKAGSCPDVNQPIPPLGVCKTTCATDSNCPDIQKCCKNGCGHMSCTRPST
-
Sequence Length
- 52
-
UniProt Entry
- A7X4J4
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02485.
Physicochemical Information
-
Formula
- C214H353N67O76S9
Absent Amino Acids
- EFWY
Common Amino Acids
- C
Mass
- 5369.1
PI
- 7.7
Basic Residues
- 6
Acidic Residues
- 4
Hydrophobic Residues
- 7
Net Charge
- +2
-
Boman Index
- -95.9
Hydrophobicity
- -0.575
Aliphatic Index
- 37.5
Half Life
-
- Mammalian:0.8 hour
- Yeast:10 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 500
Absorbance 280nm
- 9.8
Polar Residues
- 25
DRAMP02485
Comments Information
Function
- Damages membranes of susceptible bacteria. Does not inhibit the proteinases elastase and cathepsin G (By similarity).
PTM
- Contains four disulfide bonds 8-38; 21-42; 25-37; 31-47 (By similarity).
Tissue specificity
- Expressed by the venom gland.
Domain
- Contains 1 WAP domain.
Literature Information
- ·Literature 1
-
Title
- Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia).
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Pubmed ID
- 17855442
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Reference
- Mol Cell Proteomics. 2008 Feb;7(2):215-246.
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Author
- Fry BG, Scheib H, van der Weerd L, Young B, McNaughtan J, Ramjan SF, Vidal N, Poelmann RE, Norman JA.