• DRAMP ID

    • DRAMP02518
    • Peptide Name

    • NA-CATH
    • Source

    • Naja atra
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • KRFKKFFKKLKNSVKKRAKKFFKKPKVIGVTFPF
    • Sequence Length

    • 34
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.28089718] Gram-negative bacteria: Acinetobacter baumannii ATCC 9955 (MIC=10μg/ml), Acinetobacter baumannii ATCC BAA-1794 (MIC=10μg/ml), Escherichia coli ATCC 51659 (MIC=21μg/ml), K. pneumoniae ATCC 33495 (MIC=5.2μg/ml), K. pneumoniae ATCC BAA-1705 (MIC=5.2μg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=10μg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (MIC=10μg/ml)
    • Hemolytic activity

      • [Ref.28089718] 0% hemolysis at 300μg/ml against sheep red blood cells.
    • Binding Target

    • Unknown
    • Structure

    • Alpha helix, random coil
    • Structure Description

    • NA-CATH has previously been shown to be random coil in water or buffer and
    • DRAMP02518 helical wheel diagram
    • Formula

    • C206H334N54O38
    • Absent Amino Acids

    • CDEHMQWY
    • Common Amino Acids

    • K
    • Mass

    • 4764.01
    • PI

    • 12.66
    • Basic Residues

    • 15
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 13
    • Boman Index

    • -69.03
    • Hydrophobicity

    • -76.47
    • Aliphatic Index

    • 51.47
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP02518

DRAMP02518 chydropathy plot
    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.
  • Literature 1
    • Reference

    • Dev Comp Immunol. 2017 May;70:135-144.
    • Author

    • Barksdale SM, Hrifko EJ, van Hoek ML.
    • Title

    • Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae