General Information

    • DRAMP ID

    • DRAMP02518

    • Peptide Name

    • NA-CATH

    • Source

    • Naja atra

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KRFKKFFKKLKNSVKKRAKKFFKKPKVIGVTFPF

    • Sequence Length

    • 34

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.28089718] Gram-negative bacteria: Acinetobacter baumannii ATCC 9955 (MIC=10μg/ml), Acinetobacter baumannii ATCC BAA-1794 (MIC=10μg/ml), Escherichia coli ATCC 51659 (MIC=21μg/ml), K. pneumoniae ATCC 33495 (MIC=5.2μg/ml), K. pneumoniae ATCC BAA-1705 (MIC=5.2μg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=10μg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (MIC=10μg/ml)

    • Hemolytic Activity

      • [Ref.28089718] 0% hemolysis at 300μg/ml against sheep red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix, random coil

    • Structure Description

    • NA-CATH has previously been shown to be random coil in water or buffer and

    • Helical Wheel Diagram

    • DRAMP02518 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02518.

Physicochemical Information

    • Formula

    • C206H334N54O38

    • Absent Amino Acids

    • CDEHMQWY

    • Common Amino Acids

    • K

    • Mass

    • 4175.26

    • PI

    • 12.09

    • Basic Residues

    • 15

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +15

    • Boman Index

    • -69.03

    • Hydrophobicity

    • -0.765

    • Aliphatic Index

    • 51.47

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02518

DRAMP02518 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae

    • Reference

    • Dev Comp Immunol. 2017 May;70:135-144.

    • Author

    • Barksdale SM, Hrifko EJ, van Hoek ML.