• • DRAMP ID

  • DRAMP02521

• • Peptide Name

  • Cathelicidin-OH (Cathelicidin-related protein; Snakes, reptiles, animals)

• • Source

  • Ophiophagus hannah (King cobra) (Naja hannah)

• • Family

  • Belongs to the cathelicidin family.

• • Gene

  • Not found

• • Sequence

  • KFFKKLKNSVKKRAKKFFKKPRVIGVSIPF

• • Sequence Length

  • 30

• • UniProt Entry

  • B6S2X2

• • Protein Existence

  • Transcript level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram+, Antifungal

• • Target Organism

  • • [Ref.18620012]Gram-negative bacteria: Escherichia coli ATCC 25922, Escherichia coli ML-35P, Escherichia coli clinic strain, Pseudomonas aeruginosa ATCC 27853, Pseudomonas aeruginosa PA 01, Pseudomonas aeruginosa clinic strain, Enterobacter aerogenes clinic strain, Enterobacter cloacae clinic strain.
    • [Ref.22491685]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=3.125 μg/ml), Staphylococcuss aureus ATCC 43300 MRSA (MIC=6.25 μg/ml), Staphylococcuss aureus clinical strain 1 (MIC=3.125 μg/ml), Staphylococcuss aureus clinical strain 2 (MIC=6.25 μg/ml), Staphylococcuss aureus clinical strain 3 (MIC=6.25 μg/ml), Enterococcus faecalis ATCC 29212 (MIC=25 μg/ml) ;
    • Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=6.25 μg/ml), Escherichia coli ML-35p (MIC=3.125 μg/ml), Escherichia coli clinical strain 1 (MIC=6.25 μg/ml), Escherichia coli clinical strain 2 (MIC=3.125 μg/ml), Escherichia coli clinical strain 3 (MIC=1.56 μg/ml), Escherichia coli clinical strain 4 (MIC=12.5 μg/ml), Escherichia coli clinical strain 5 (MIC=3.125 μg/ml), Escherichia coli clinical strain 6 (MIC=3.125 μg/ml), Enterobacter cloacae ATCC 13047 (MIC=25 μg/ml), Enterobacter cloacae clinical strain (MIC=3.125 μg/ml), Enterobacter aerogenes clinical strain (MIC=6.25 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=6.25 μg/ml), Pseudomonas aeruginosa PA 01 (MIC=6.25 μg/ml), Pseudomonas aeruginosa clinical strain 1 (MIC=12.5 μg/ml), Pseudomonas aeruginosa clinical strain 2 (MIC=6.25 μg/ml), Haemophilus influenzae ATCC 49247 (MIC=3.125 μg/ml), Haemophilus influenzae ATCC 49766 (MIC=3.125 μg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=6.25 μg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=3.125 μg/ml) ;
    • Fungi : Candida albicans ATCC 2002 (MIC>200 μg/ml), Candida albicans clinical strain (MIC>200 μg/ml)

• • Hemolytic Activity

  • • [Ref.22491685] 3% hemolysis at 100 μg/ml , 5% hemolysis at 200 μg/ml , 6% hemolysis at 300 μg/ml , 7% hemolysis at 400 μg/ml against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Cell membrane

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 2mwt resolved by NMR

• Predicted Structure

• There is no predicted structure for DRAMP02521.

DRAMP02521

• • [Ref.22491685]Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans

• ·Literature 1

• • Title

  • Identification and characterization of novel reptile cathelicidins from elapid snakes.

• • Pubmed ID

  • 18620012

• • Reference

  • Peptides. 2008 Oct;29(10):1685-91.

• • Author

  • Zhao H, Gan TX, Liu XD, Jin Y, Lee WH, Shen JH, Zhang Y.

• ·Literature 2

• • Title

  • Efficacy of OH-CATH30 and Its Analogs against Drug-ResistantBacteria In Vitro and in Mouse Models

• • Pubmed ID

  • 22491685

• • Reference

  • Antimicrob Agents Chemother. 2012 Jun;56(6):3309-17. doi: 10.1128/AAC.06304-11.

• • Author

  • Sheng-An Li, Wen-Hui Lee, and Yun Zhang