General Information
-
DRAMP ID
- DRAMP02526
-
Peptide Name
- CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin)
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Source
- Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630/ NBRC 100827)
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Family
- Belongs to the CRISPR-associated endoribonuclease Cas2 prote
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Gene
- cas2-1
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Sequence
- MIWLAVYDIEDDGERAKASAILQAWGFVRVQRSFYVGRMPRGKAADLLKILQRHVKSGHIALIPITDELLAKALELGRPPYAPLKPPKYAQIYVV
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Sequence Length
- 95
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UniProt Entry
- Q8ZZU2
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Metal-binding
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02526.
Physicochemical Information
-
Formula
- C496H791N133O127S2
Absent Amino Acids
- CN
Common Amino Acids
- AL
Mass
- 10713.67
PI
- 9.69
Basic Residues
- 16
Acidic Residues
- 9
Hydrophobic Residues
- 42
Net Charge
- +7
-
Boman Index
- -94.64
Hydrophobicity
- 0.026
Aliphatic Index
- 112
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 18450
Absorbance 280nm
- 196.28
Polar Residues
- 15
DRAMP02526
Comments Information
Function
- CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).
Literature Information
- ·Literature 1
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Title
- Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.
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Pubmed ID
- 11792869
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Reference
- Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):984-989.
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Author
- Fitz-Gibbon ST, Ladner H, Kim UJ, Stetter KO, Simon MI, Miller JH.