General Information
-
DRAMP ID
- DRAMP02553
-
Peptide Name
- CRISPR-associated endoribonuclease Cas2 (Antiviral defensin)
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Source
- Korarchaeum cryptofilum (strain OPF8)
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Family
- Belongs to the CRISPR-associated endoribonuclease Cas2 prote
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Gene
- cas2
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Sequence
- MRGGNLKVLVVYDITDDSLRLKVAEILKDLGLFRIQKSAFIGEMTSQERENMEEILRRQNLGPSDRIDVFPICDRDLKMHSQIGRGKFGRGPP
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Sequence Length
- 93
-
UniProt Entry
- B1L402
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Metal-binding
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02553.
Physicochemical Information
-
Formula
- C464H766N138O137S5
Absent Amino Acids
- W
Common Amino Acids
- LRG
Mass
- 10630.33
PI
- 8.93
Basic Residues
- 17
Acidic Residues
- 14
Hydrophobic Residues
- 29
Net Charge
- +3
-
Boman Index
- -218.7
Hydrophobicity
- -0.451
Aliphatic Index
- 93.23
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 16.2
Polar Residues
- 21
DRAMP02553
Comments Information
Function
- CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).
Literature Information
- ·Literature 1
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Title
- A korarchaeal genome reveals insights into the evolution of the Archaea.
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Pubmed ID
- 18535141
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Reference
- Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8102-8107.
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Author
- Elkins JG, Podar M, Graham DE, Makarova KS, Wolf Y, Randau L, Hedlund BP, Brochier-Armanet C, Kunin V, Anderson I, Lapidus A, Goltsman E, Barry K, Koonin EV, Hugenholtz P, Kyrpides N, Wanner G, Richardson P, Keller M, Stetter KO.