General Information

    • DRAMP ID

    • DRAMP02555

    • Peptide Name

    • CRISPR-associated endoribonuclease Cas2 (Antiviral defensin)

    • Source

    • Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /C2A)

    • Family

    • Belongs to the CRISPR-associated endoribonuclease Cas2 prote

    • Gene

    • cas2

    • Sequence

    • MYVVIVYDVGVERVNKVRSFLREYMNWVQNSVFEGELTKAEFLKIKSRLKELIQESSDHIIFYSSRDRKYLGIEDLGTPKADTSNII

    • Sequence Length

    • 87

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Metal-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02555 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02555.

Physicochemical Information

    • Formula

    • C462H731N121O136S2

    • Absent Amino Acids

    • C

    • Common Amino Acids

    • VEIS

    • Mass

    • 10220.74

    • PI

    • 6.58

    • Basic Residues

    • 14

    • Acidic Residues

    • 13

    • Hydrophobic Residues

    • 31

    • Net Charge

    • +1

    • Boman Index

    • -167.87

    • Hydrophobicity

    • -0.277

    • Aliphatic Index

    • 99.54

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 12950

    • Absorbance 280nm

    • 150.58

    • Polar Residues

    • 24

DRAMP02555

DRAMP02555 chydropathy plot

Comments Information

    • Function

    • CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • The genome of M. acetivorans reveals extensive metabolic and physiological diversity.

    • Reference

    • Genome Res. 2002 Apr;12(4):532-542.

    • Author

    • Galagan JE, Nusbaum C, Roy A, Endrizzi MG, Macdonald P, FitzHugh W, Calvo S, Engels R, Smirnov S, Atnoor D, Brown A, Allen N, Naylor J, Stange-Thomann N, DeArellano K, Johnson R, Linton L, McEwan P, McKernan K, Talamas J, Tirrell A, Ye W, Zimmer A, Barber RD, Cann I, Graham DE, et al.