General Information
-
DRAMP ID
- DRAMP02558
-
Peptide Name
- CRISPR-associated endoribonuclease Cas2 (Antiviral defensin)
-
Source
- Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM13430 / M1) (Methanobacterium rumi
-
Family
- Belongs to the CRISPR-associated endoribonuclease Cas2 prote
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Gene
- cas2
-
Sequence
- MKVLVSFEIKFKTNKEKIISILKHFGFRRMQENLYFGDVEYDELYAMQSDIMENIREYDSILTIPICKSCYLKLNVFGRNLSFKDELYKIF
-
Sequence Length
- 91
-
UniProt Entry
- D3E4V5
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Metal-binding
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02558.
Physicochemical Information
-
Formula
- C506H786N122O139S6
Absent Amino Acids
- W
Common Amino Acids
- IKL
Mass
- 10994.9
PI
- 7.72
Basic Residues
- 15
Acidic Residues
- 13
Hydrophobic Residues
- 32
Net Charge
- +2
-
Boman Index
- -138.51
Hydrophobicity
- -0.156
Aliphatic Index
- 95.27
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 9065
Absorbance 280nm
- 100.72
Polar Residues
- 24
DRAMP02558
Comments Information
Function
- CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).
Literature Information
- ·Literature 1
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Title
- The genome sequence of the rumen methanogen Methanobrevibacter ruminantium reveals new possibilities for controlling ruminant methane emissions.
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Pubmed ID
- 20126622
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Reference
- PLoS One. 2010 Jan 28;5(1):e8926.
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Author
- Leahy SC, Kelly WJ, Altermann E, Ronimus RS, Yeoman CJ, Pacheco DM, Li D, Kong Z, McTavish S, Sang C, Lambie SC, Janssen PH, Dey D, Attwood GT.