General Information
-
DRAMP ID
- DRAMP02575
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Peptide Name
- Penaeidin-3b (Pen-3b; shrimps, Arthropods, animals)
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Source
- Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)
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Family
- Belongs to the penaeidin family
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Gene
- Not found
-
Sequence
- QVYKGGYTRPVPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS
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Sequence Length
- 62
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UniProt Entry
- P81059
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacterium: Micrococcus luteus;
- Gram-negative bacterium: Escherichia coli.
- Fungi: Neurospora crassa, Fusarium oxysporum.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Chitin-binding
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02575.
Physicochemical Information
-
Formula
- C290H454N90O77S6
Absent Amino Acids
- DEMW
Common Amino Acids
- GP
Mass
- 6625.71
PI
- 9.89
Basic Residues
- 10
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- +10
-
Boman Index
- -96.72
Hydrophobicity
- -0.382
Aliphatic Index
- 50.16
Half Life
-
- Mammalian:0.8 hour
- Yeast:10 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 6335
Absorbance 280nm
- 103.85
Polar Residues
- 28
DRAMP02575
Comments Information
Function
- Posesses antibacterial and antifungal activity. Presents chitin-binding activity.
Subcellular location
- Cytoplasmic granule. Note
Tissue specificity
- Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain.
Developmental stage
- Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours.
PTM
- Contains three disulfide bonds 32-47; 36-54; 48-55, Pyrrolidone carboxylic acid and Lysine amide at position 1 and 62 respectively.
Literature Information
- ·Literature 1
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Title
- Penaeidins, a family of antimicrobial peptides from penaeid shrimp (Crustacea, Decapoda).
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Pubmed ID
- 11028917
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Reference
- Cell Mol Life Sci. 2000 Aug;57(8-9):1260-1271.
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Author
- Destoumieux D, Munoz M, Bulet P, Bachère E.
- ·Literature 2
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Title
- Penaeidins, antimicrobial peptides with chitin-binding activity, are produced and stored in shrimp granulocytes and released after microbial challenge.
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Pubmed ID
- 10639333
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Reference
- J Cell Sci. 2000 Feb;113 (Pt 3):461-469.
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Author
- Destoumieux D, Muñoz M, Cosseau C, Rodriguez J, Bulet P, Comps M, Bachère E.