General Information

    • DRAMP ID

    • DRAMP02600

    • Peptide Name

    • Clavanin-D (His-rich; chordates, animals)

    • Source

    • Styela clava (Sea squirt)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AFKLLGRIIHHVGNFVYGFSHVF

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • yeast Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02600 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02600.

Physicochemical Information

    • Formula

    • C130H188N34O27

    • Absent Amino Acids

    • CDEMPQTW

    • Common Amino Acids

    • F

    • Mass

    • 2659.13

    • PI

    • 10

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +5

    • Boman Index

    • 3.72

    • Hydrophobicity

    • 0.757

    • Aliphatic Index

    • 110

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 67.73

    • Polar Residues

    • 6

DRAMP02600

DRAMP02600 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity.

    • Tissue specificity

    • Hemocytes and pharyngeal tissues.

Literature Information

  • ·Literature 1

    • Title

    • cDNA cloning of Clavanins: antimicrobial peptides of tunicate hemocytes.

    • Reference

    • FEBS Lett. 1997 Jun 30;410(2-3):490-492.

    • Author

    • Zhao C, Liaw L, Lee IH, Lehrer RI.
  • ·Literature 2

    • Title

    • Clavanins, alpha-helical antimicrobial peptides from tunicate hemocytes.

    • Reference

    • FEBS Lett. 1997 Jan 3;400(2):158-162.

    • Author

    • Lee IH, Zhao C, Cho Y, Harwig SS, Cooper EL, Lehrer RI.