General Information

    • DRAMP ID

    • DRAMP02601

    • Peptide Name

    • Clavanin E (His-rich; chordates, animals)

    • Source

    • Styela clava (Sea squirt)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LFKLLGKIIHHVGNFVHGFSHVF

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • yeast Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02601 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02601.

Physicochemical Information

    • Formula

    • C130H192N34O26

    • Absent Amino Acids

    • ACDEMPQRTWY

    • Common Amino Acids

    • FH

    • Mass

    • 2647.17

    • PI

    • 10

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +6

    • Boman Index

    • 11.68

    • Hydrophobicity

    • 0.787

    • Aliphatic Index

    • 122.61

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP02601

DRAMP02601 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity.

Literature Information

  • ·Literature 1

    • Title

    • cDNA cloning of Clavanins: antimicrobial peptides of tunicate hemocytes.

    • Reference

    • FEBS Lett. 1997 Jun 30;410(2-3):490-492.

    • Author

    • Zhao C, Liaw L, Lee IH, Lehrer RI.