General Information
-
DRAMP ID
- DRAMP02602
-
Peptide Name
- Clavaspirin (chordates, animals)
-
Source
- Styela clava (Sea squirt)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- FLRFIGSVIHGIGHLVHHIGVAL
-
Sequence Length
- 23
-
UniProt Entry
- O97395
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
- [Swiss_Prot Entry O97395]Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria
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Hemolytic Activity
-
- [Ref.12005415]has potent hemolytic activity
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02602.
Physicochemical Information
-
Formula
- C119H186N34O25
Absent Amino Acids
- CDEKMNPQTWY
Common Amino Acids
- GHI
Mass
- 2493
PI
- 9.78
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 13
Net Charge
- +5
-
Boman Index
- 21.13
Hydrophobicity
- 1.291
Aliphatic Index
- 160.87
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP02602
Comments Information
Function
- Has potent hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Clavaspirin, an antibacterial and haemolytic peptide from Styela clava.
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Pubmed ID
- 12005415
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Reference
- J Pept Res. 2001 Dec;58(6):445-456.
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Author
- Lee IH, Zhao C, Nguyen T, Menzel L, Waring AJ, Sherman MA, Lehrer RI.