General Information

    • DRAMP ID

    • DRAMP02603

    • Peptide Name

    • Putative antimicrobial peptide A Northern Europe Heligoland (chordates, animals)

    • Source

    • Ciona intestinalis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AALRGALRAVARVGKAILPHVAIANPYVRTPYVHNNP

    • Sequence Length

    • 37

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Bacillus megaterium (MIC=0.1 µM), Bacillus subtilis (MIC=3.1 µM), Staphylococcus aureus (MIC>25 µM), Staphylococcus epidermidis (MIC=25 µM).
      • Gram-negative bacteria: Escherichia coli K12 D31 (MIC=0.8 µM), Y. enterocolitica (MIC=3.1 µM), Klebsiella pneumoniae (MIC>25µM), Pseudomonas aeruginosa (MIC=12.5 µM), Serratia marcescens(MIC>25 µM).
      • Fungi: Candida albicans ATCC 10261 (MIC=6.3 µM), Candida albicans SC 5314 (MIC=6.3 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02603 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C179H293N57O44

    • Absent Amino Acids

    • CDEFMQSW

    • Common Amino Acids

    • A

    • Mass

    • 3947.65

    • PI

    • 11.57

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 18

    • Net Charge

    • +7

    • Boman Index

    • -36.16

    • Hydrophobicity

    • 0.176

    • Aliphatic Index

    • 113.51

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 82.78

    • Polar Residues

    • 8

DRAMP02603

DRAMP02603 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • A reverse search for antimicrobial peptides in Ciona intestinalis: identification of a gene family expressed in hemocytes and evaluation of activity.

    • Reference

    • Dev Comp Immunol. 2008;32(3):286-298.

    • Author

    • Fedders H, Leippe M.