General Information
-
DRAMP ID
- DRAMP02606
-
Peptide Name
- Antibacterial protein LL-37 (cathelicidin; primates, mammals, animals)
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Source
- Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata)
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Family
- Belongs to the cathelicidin family
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Gene
- CAMP
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Sequence
- RLGNFFRKAKEKIGRGLKKIGQKIKDFWGNLVPRTES
-
Sequence Length
- 37
-
UniProt Entry
- Q1KLX5
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Lipopolysaccharide (LPS)-binding
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02606.
Physicochemical Information
-
Formula
- C197H324N60O49
Absent Amino Acids
- CHMY
Common Amino Acids
- K
Mass
- 4317.11
PI
- 11.13
Basic Residues
- 11
Acidic Residues
- 3
Hydrophobic Residues
- 12
Net Charge
- +8
-
Boman Index
- -94.32
Hydrophobicity
- -0.892
Aliphatic Index
- 73.78
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 152.78
Polar Residues
- 9
DRAMP02606
Comments Information
Function
- Has antibacterial activity. (By similarity)
Literature Information
- ·Literature 1
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Title
- Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.
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Pubmed ID
- 16720578
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Reference
- J Biol Chem. 2006 Jul 21;281(29):19861-19871.
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Author
- Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A.