General Information
-
DRAMP ID
- DRAMP02614
-
Peptide Name
- Beta-defensin 105A (Defensin, beta 105; Defensin, beta 105A; primates, mammals, animals)
-
Source
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
-
Family
- Belongs to the beta-defensin family
-
Gene
- DEFB105A
-
Sequence
- GLEFSEPFPSGRFAVCESCKLGRGKCRKECLENEKPDGSCRLNFLCCRPRM
-
Sequence Length
- 51
-
UniProt Entry
- A4H209
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02614.
Physicochemical Information
-
Formula
- C244H393N75O72S8
Absent Amino Acids
- HIQTWY
Common Amino Acids
- CER
Mass
- 5785.74
PI
- 8.58
Basic Residues
- 10
Acidic Residues
- 7
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- -129.8
Hydrophobicity
- -0.59
Aliphatic Index
- 45.88
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 375
Absorbance 280nm
- 7.5
Polar Residues
- 18
DRAMP02614
Comments Information
Function
- Has antimicrobial activity (By similarity).
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
-
Title
- Evolution and sequence variation of human beta-defensin genes.
-
Pubmed ID
- PubMed ID is not available
-
Reference
- Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
-
Author
- Hollox E.J, Armour J.A.L.