General Information

    • DRAMP ID

    • DRAMP02623

    • Peptide Name

    • Macaque histatin (His-rich; M-Histatin 1; primates, mammals, animals)

    • Source

    • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

    • Family

    • Belongs to the histatin family

    • Gene

    • HTN1

    • Sequence

    • DSHEERHHGRHGHHKYGRKFHEKHHSHRGYRSNYLYDN

    • Sequence Length

    • 38

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02623 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02623.

Physicochemical Information

    • Formula

    • C207H294N78O58

    • Absent Amino Acids

    • ACIMPQTVW

    • Common Amino Acids

    • H

    • Mass

    • 4803.1

    • PI

    • 9.6

    • Basic Residues

    • 18

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +13

    • Boman Index

    • -188.1

    • Hydrophobicity

    • -2.455

    • Aliphatic Index

    • 10.26

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5960

    • Absorbance 280nm

    • 161.08

    • Polar Residues

    • 13

DRAMP02623

DRAMP02623 chydropathy plot

Comments Information

    • Function

    • Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.

Literature Information

  • ·Literature 1

    • Title

    • Primary structure and anticandidal activity of the major histatin from parotid secretion of the subhuman primate, Macaca fascicularis.

    • Reference

    • J Dent Res. 1990 Nov;69(11):1717-1723.

    • Author

    • Xu T, Telser E, Troxler RF, Oppenheim FG.