General Information
-
DRAMP ID
- DRAMP02639
-
Peptide Name
- Demidefensin-3 (primates, mammals, animals)
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Source
- Macaca mulatta (Rhesus macaque)
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Family
- Belongs to the alpha-defensin family
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Gene
- Not found
-
Sequence
- RCICVLGIC
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Sequence Length
- 9
-
UniProt Entry
- Q9GLR2
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02639.
Physicochemical Information
-
Formula
- C40H74N12O10S3
Absent Amino Acids
- ADEFHKMNPQSTWY
Common Amino Acids
- C
Mass
- 979.28
PI
- 7.97
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +1
-
Boman Index
- 8.66
Hydrophobicity
- 2.178
Aliphatic Index
- 162.22
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 15.63
Polar Residues
- 4
DRAMP02639
Comments Information
Function
- Has antimicrobial activities against bacteria and fungi (By similarity).
Subunit structure
- Forms a cyclic homodimer; disulfide-linked (By similarity).
PTM
- This is a cyclic peptide (By similarity).
Caution
- The mature 9-residue peptide is expected to be found in 18-residue cyclopeptides produced by combinatorial peptide splicing either with itself or with other demidefensins. However among cyclopeptides screened for antimicrobial activity, no peptides that would have been produced from this sequence were detected.
Literature Information
- ·Literature 1
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Title
- Circular minidefensins and posttranslational generation of molecular diversity.
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Pubmed ID
- 11527997
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Reference
- J Leukoc Biol. 2001 Sep;70(3):461-464.
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Author
- Leonova L, Kokryakov VN, Aleshina G, Hong T, Nguyen T, Zhao C, Waring AJ, Lehrer RI.