General Information

    • DRAMP ID

    • DRAMP02645

    • Peptide Name

    • Rhesus theta-defensin 4 (RTD-4; primates, mammals, animals)

    • Source

    • Macaca mulatta (Rhesus macaque)

    • Family

    • Belongs to the alpha-defensin family (Theta subfamily)

    • Gene

    • Not found

    • Sequence

    • GICRCICTRGFCRCICVL

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02645 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02645.

Physicochemical Information

    • Formula

    • C82H143N27O20S6

    • Absent Amino Acids

    • ADEHKMNPQSWY

    • Common Amino Acids

    • C

    • Mass

    • 2019.57

    • PI

    • 8.72

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -11.07

    • Hydrophobicity

    • 1.35

    • Aliphatic Index

    • 102.78

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 22.06

    • Polar Residues

    • 9

DRAMP02645

DRAMP02645 chydropathy plot

Comments Information

    • Function

    • RTD-1 and RTD-5 are 3-fold more active than RTD-4.

Literature Information

  • ·Literature 1

    • Title

    • Rhesus macaque {theta}-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities.

    • Reference

    • J Leukoc Biol. 2011 Feb;89(2):283-290.

    • Author

    • Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME.