General Information
-
DRAMP ID
- DRAMP02646
-
Peptide Name
- Rhesus theta-defensin 5 (RTD-5; primates, mammals, animals)
-
Source
- Macaca mulatta (Rhesus macaque)
-
Family
- Belongs to the alpha-defensin family (Theta subfamily)
-
Gene
- Not found
-
Sequence
- GICRCLCRRGVCRCICVL
-
Sequence Length
- 18
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02646.
Physicochemical Information
-
Formula
- C80H148N30O19S6
Absent Amino Acids
- ADEFHKMNPQSTWY
Common Amino Acids
- C
Mass
- 2026.6
PI
- 9.01
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +4
-
Boman Index
- -22.36
Hydrophobicity
- 1.178
Aliphatic Index
- 118.89
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 375
Absorbance 280nm
- 22.06
Polar Residues
- 8
DRAMP02646
Comments Information
Function
- RTD-1 and RTD-5 are 3-fold more active than RTD-4. RTD-6 has not be collected due to the lack of activity.
Literature Information
- ·Literature 1
-
Title
- Rhesus macaque {theta}-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities.
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Pubmed ID
- 21084627
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Reference
- J Leukoc Biol. 2011 Feb;89(2):283-290.
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Author
- Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME.