General Information

    • DRAMP ID

    • DRAMP02653

    • Peptide Name

    • Neutrophil defensin 1 (RMAD-1; primates, mammals, animals)

    • Source

    • Macaca mulatta (Rhesus macaque)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • ACYCRIPACLAGERRYGTCFYLGRVWAFCC

    • Sequence Length

    • 30

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;
      • Gram-negative bacterium: Escherichia coli.
      • Fungi: Cryptococcus neoformans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02653 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02653.

Physicochemical Information

    • Formula

    • C153H227N43O37S6

    • Absent Amino Acids

    • DHKMNQS

    • Common Amino Acids

    • C

    • Mass

    • 3453.11

    • PI

    • 8.68

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -24.65

    • Hydrophobicity

    • 0.477

    • Aliphatic Index

    • 62

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 10345

    • Absorbance 280nm

    • 356.72

    • Polar Residues

    • 13

DRAMP02653

DRAMP02653 chydropathy plot

Comments Information

    • Function

    • Has antibacterial and antifungal activiy.

Literature Information

  • ·Literature 1

    • Title

    • Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes.

    • Reference

    • Infect Immun. 1999 Nov;67(11):6139-6144.

    • Author

    • Tang YQ, Yuan J, Miller CJ, Selsted ME.