• DRAMP ID

    • DRAMP02654
    • Peptide Name

    • Neutrophil defensin 2 (RMAD-2; primates, mammals, animals)
    • Source

    • Macaca mulatta (Rhesus macaque)
    • Family

    • Belongs to the alpha-defensin family
    • Gene

    • Not found
    • Sequence

    • ACYCRIPACLAGERRYGTCFYMGRVWAFCC
    • Sequence Length

    • 30
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;
      • Gram-negative bacterium: Escherichia coli.
      • Fungi: Cryptococcus neoformans.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02654 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02654.
    • Formula

    • C152H225N43O37S7
    • Absent Amino Acids

    • DHKNQS
    • Common Amino Acids

    • C
    • Mass

    • 3471.14
    • PI

    • 8.68
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +3
    • Boman Index

    • -27.22
    • Hydrophobicity

    • 0.413
    • Aliphatic Index

    • 49
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 10345
    • Absorbance 280nm

    • 356.72
    • Polar Residues

    • 13

DRAMP02654

DRAMP02654 chydropathy plot
    • Function

    • Has antibacterial and antifungal activiy.
  • ·Literature 1
    • Title

    • Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes.
    • Reference

    • Infect Immun. 1999 Nov;67(11):6139-6144.
    • Author

    • Tang YQ, Yuan J, Miller CJ, Selsted ME.