• DRAMP ID

    • DRAMP02659
    • Peptide Name

    • Neutrophil defensin 3 (RMAD-3; primates, mammals, animals)
    • Source

    • Macaca mulatta (Rhesus monkey)
    • Family

    • Belongs to the alpha-defensin family
    • Gene

    • Not found
    • Sequence

    • ACYCRIPACLAGERRYGTCFYRRRVWAFCC
    • Sequence Length

    • 30
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;
      • Gram-negative bacteria: Escherichia coli.
      • Fungi: Cryptococcus neoformans.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02659 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02659.
    • Formula

    • C157H237N49O37S6
    • Absent Amino Acids

    • DHKMNQS
    • Common Amino Acids

    • CR
    • Mass

    • 3595.28
    • PI

    • 9.18
    • Basic Residues

    • 6
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +5
    • Boman Index

    • -60.35
    • Hydrophobicity

    • 0.063
    • Aliphatic Index

    • 49
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 10345
    • Absorbance 280nm

    • 356.72
    • Polar Residues

    • 12

DRAMP02659

DRAMP02659 chydropathy plot
    • Function

    • Has bacteriostatic and antifungal activity.
    • PTM

    • Contains three disulfide bonds
  • ·Literature 1
    • Title

    • Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes.
    • Reference

    • Infect Immun. 1999 Nov;67(11):6139-6144.
    • Author

    • Tang YQ, Yuan J, Miller CJ, Selsted ME.