General Information

    • DRAMP ID

    • DRAMP02660

    • Peptide Name

    • Neutrophil defensin 4 (RMAD-4; primates, mammals, animals)

    • Source

    • Macaca mulatta (Rhesus monkey)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • RRTCRCRFGRCFRRESYSGSCNINGRIFSLCCR

    • Sequence Length

    • 33

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;
      • Gram-negative bacteria: Escherichia coli.
      • Fungi: Cryptococcus neoformans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02660 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP02660.

Physicochemical Information

    • Formula

    • C161H264N62O44S6

    • Absent Amino Acids

    • ADHKMPQVW

    • Common Amino Acids

    • R

    • Mass

    • 3964.62

    • PI

    • 10.6

    • Basic Residues

    • 9

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +8

    • Boman Index

    • -136.48

    • Hydrophobicity

    • -0.642

    • Aliphatic Index

    • 35.45

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 58.28

    • Polar Residues

    • 17

DRAMP02660

DRAMP02660 chydropathy plot

Comments Information

    • Function

    • Defensins 4 has bacteriostatic and antifungal activity.

    • PTM

    • Contains three disulfide bonds 4-32; 6-21; 11-31.

Literature Information

  • ·Literature 1

    • Title

    • Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes.

    • Reference

    • Infect Immun. 1999 Nov;67(11):6139-6144.

    • Author

    • Tang YQ, Yuan J, Miller CJ, Selsted ME.