General Information

    • DRAMP ID

    • DRAMP02661

    • Peptide Name

    • Neutrophil defensin 5 (RMAD-5; primates, mammals, animals)

    • Source

    • Macaca mulatta (Rhesus monkey)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • RTCRCRFGRCFRRESYSGSCNINGRIFSLCCR

    • Sequence Length

    • 32

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;
      • Gram-negative bacteria: Escherichia coli.
      • Fungi: Cryptococcus neoformans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02661 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP02661.

Physicochemical Information

    • Formula

    • C155H252N58O43S6

    • Absent Amino Acids

    • ADHKMPQVW

    • Common Amino Acids

    • R

    • Mass

    • 3808.43

    • PI

    • 9.98

    • Basic Residues

    • 8

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +7

    • Boman Index

    • -121.56

    • Hydrophobicity

    • -0.522

    • Aliphatic Index

    • 36.56

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 60.16

    • Polar Residues

    • 17

DRAMP02661

DRAMP02661 chydropathy plot

Comments Information

    • Function

    • Defensins 5 has bacteriostatic and antifungal activity.

    • PTM

    • Contains three disulfide bonds 3-31; 5-20; 10-30.

Literature Information

  • ·Literature 1

    • Title

    • Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes.

    • Reference

    • Infect Immun. 1999 Nov;67(11):6139-6144.

    • Author

    • Tang YQ, Yuan J, Miller CJ, Selsted ME.