General Information

    • DRAMP ID

    • DRAMP02670

    • Peptide Name

    • Neutrophil defensin 4 (Defensin, alpha 4; primates, mammals, animals)

    • Source

    • Pan troglodytes (chimpanzee)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • DEFA4

    • Sequence

    • VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD

    • Sequence Length

    • 34

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02670 helical wheel diagram
  • 1ZMM-> 

    • Predicted Structure

    • There is no predicted structure for DRAMP02670.

Physicochemical Information

    • Formula

    • C161H266N50O46S6

    • Absent Amino Acids

    • AHKMPQW

    • Common Amino Acids

    • C

    • Mass

    • 3830.55

    • PI

    • 8.7

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -55.08

    • Hydrophobicity

    • 0.538

    • Aliphatic Index

    • 88.53

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 56.52

    • Polar Residues

    • 16

DRAMP02670

DRAMP02670 chydropathy plot

Comments Information

    • Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production.

Literature Information

  • ·Literature 1

    • Title

    • Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.

    • Reference

    • Physiol Genomics. 2004 Dec 15;20(1):1-11.

    • Author

    • Patil A, Hughes AL, Zhang G.