General Information
-
DRAMP ID
- DRAMP02679
-
Peptide Name
- Beta-defensin109 (Defensin, beta 109; Defensin, beta 109; primates, mammals, animals)
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Source
- Pan troglodytes (Chimpanzee)
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Family
- Belongs to the beta-defensin family
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Gene
- DEFB109
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Sequence
- GLGPAEGHCLNLSGVCRRDVCKVVEDQIGACRRRMKCCRAWWILMPIPTPLIMSDYQEPLKRKLK
-
Sequence Length
- 65
-
UniProt Entry
- Q30KL7
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02679.
Physicochemical Information
-
Formula
- C323H536N98O85S9
Absent Amino Acids
- F
Common Amino Acids
- LRC
Mass
- 7440.95
PI
- 9.3
Basic Residues
- 13
Acidic Residues
- 6
Hydrophobic Residues
- 20
Net Charge
- +7
-
Boman Index
- -110.87
Hydrophobicity
- -0.209
Aliphatic Index
- 88.46
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 12865
Absorbance 280nm
- 201.02
Polar Residues
- 16
DRAMP02679
Comments Information
Function
- Has antibacterial activity (By similarity).
PYM
- Problely contrains three disulfide bonds.
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.