General Information
-
DRAMP ID
- DRAMP02683
-
Peptide Name
- Beta-defensin 121 (Defensin, beta 121; primates, mammals, animals)
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Source
- Pan troglodytes (Chimpanzee)
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Family
- Belongs to the beta-defensin family
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Gene
- DEFB121
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Sequence
- QVTPVMKCWGKSGRCRTTCKESEVYYILCKTEAKCCVDPKYVPVKPKLTDRNTSLESTSAV
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Sequence Length
- 61
-
UniProt Entry
- Q30KK6
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02683.
Physicochemical Information
-
Formula
- C296H487N81O91S7
Absent Amino Acids
- FH
Common Amino Acids
- KTV
Mass
- 6861.03
PI
- 9
Basic Residues
- 11
Acidic Residues
- 6
Hydrophobic Residues
- 14
Net Charge
- +5
-
Boman Index
- -115.61
Hydrophobicity
- -0.456
Aliphatic Index
- 62.13
Half Life
-
- Mammalian:0.8 hour
- Yeast:10 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 10345
Absorbance 280nm
- 172.42
Polar Residues
- 24
DRAMP02683
Comments Information
Function
- Has antibacterial activity.
PTM
- Problely contains three disulfide bonds 8-35; 15-29; 19-36.
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.