General Information
-
DRAMP ID
- DRAMP02684
-
Peptide Name
- Beta-defensin 124 (Defensin, beta 124; Defensin, beta 126; primates, mammals, animals)
-
Source
- Pan troglodytes (Chimpanzee)
-
Family
- Belongs to the beta-defensin family
-
Gene
- DEFB124
-
Sequence
- EFKRCWKGQGACRTYCTRQETYMHLCPDASLCCLSYALKPPPVPKHEYE
-
Sequence Length
- 49
-
UniProt Entry
- Q30KK4
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02684.
Physicochemical Information
-
Formula
- C252H383N69O71S7
Absent Amino Acids
- IN
Common Amino Acids
- C
Mass
- 5739.65
PI
- 8.32
Basic Residues
- 9
Acidic Residues
- 5
Hydrophobic Residues
- 10
Net Charge
- +4
-
Boman Index
- -92.02
Hydrophobicity
- -0.696
Aliphatic Index
- 43.88
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11835
Absorbance 280nm
- 246.56
Polar Residues
- 17
DRAMP02684
Comments Information
Function
- Has antibacterial activity.
PTM
- Problely contains three disulfide bonds 5-32; 12-26; 16-33.
Literature Information
- ·Literature 1
-
Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
-
Pubmed ID
- 16033865
-
Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
-
Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.