General Information

    • DRAMP ID

    • DRAMP02714

    • Peptide Name

    • Antibacterial protein LL-37 (cathelicidin; primates, mammals,animals)

    • Source

    • Pongo pygmaeus (Bornean orangutan)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • CAMP

    • Sequence

    • LLGDFFRKAREKIGEEFKRIVQRIKDFLRNLVPRTES

    • Sequence Length

    • 37

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Lipopolysaccharides (LPS)

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02714 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02714.

Physicochemical Information

    • Formula

    • C204H335N61O54

    • Absent Amino Acids

    • CHMWY

    • Common Amino Acids

    • R

    • Mass

    • 4506.28

    • PI

    • 10.4

    • Basic Residues

    • 10

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +4

    • Boman Index

    • -116.42

    • Hydrophobicity

    • -0.66

    • Aliphatic Index

    • 92.16

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP02714

DRAMP02714 chydropathy plot

Comments Information

    • Function

    • Problrly has antibacterial activity.

Literature Information

  • ·Literature 1

    • Title

    • Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.

    • Reference

    • J Biol Chem. 2006 Jul 21;281(29):19861-19871.

    • Author

    • Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A.