General Information
-
DRAMP ID
- DRAMP02716
-
Peptide Name
- Beta-defensin 105A (Defensin, beta 105; Defensin, beta 105A; primates, mammals,animals)
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Source
- Pongo pygmaeus (Bornean orangutan)
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Family
- Belongs to the beta-defensin family
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Gene
- DEFB105A
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Sequence
- GLDFSQPFPSDEFAVCESCKLGRGKCRKECLENEKPDGNCRLNFLCCRERI
-
Sequence Length
- 51
-
UniProt Entry
- A4H207
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02716.
Physicochemical Information
-
Formula
- C246H392N74O77S7
Absent Amino Acids
- HMTWY
Common Amino Acids
- CE
Mass
- 5842.69
PI
- 6.37
Basic Residues
- 9
Acidic Residues
- 9
Hydrophobic Residues
- 12
Net Charge
- 0
-
Boman Index
- -139.47
Hydrophobicity
- -0.671
Aliphatic Index
- 53.53
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 375
Absorbance 280nm
- 7.5
Polar Residues
- 17
DRAMP02716
Comments Information
Function
- Has antimicrobial activity (By similarity).
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Evolution and sequence variation of human beta-defensin genes.
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Pubmed ID
- PubMed ID is not available
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Reference
- Submitted (NOV-2006) to the EMBL/GenBank/DDBJ database
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Author
- Hollox E.J, Armour J.A.L.