General Information
-
DRAMP ID
- DRAMP02724
-
Peptide Name
- Antibacterial protein LL-37 (cathelicidin; primates, mammals, animals)
-
Source
- Nomascus gabriellae (Red-cheeked gibbon)
-
Family
- Belongs to the cathelicidin family
-
Gene
- CAMP
-
Sequence
- LPGNFFRKAREKIGKEFKRIVQRIKDFLQHLVPRTEA
-
Sequence Length
- 37
-
UniProt Entry
- Q1KLY2
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Lipopolysaccharide (LPS)-binding
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02724.
Physicochemical Information
-
Formula
- C205H334N62O50
Absent Amino Acids
- CMSWY
Common Amino Acids
- KR
Mass
- 4467.29
PI
- 11
Basic Residues
- 11
Acidic Residues
- 4
Hydrophobic Residues
- 14
Net Charge
- +7
-
Boman Index
- -101.43
Hydrophobicity
- -0.711
Aliphatic Index
- 84.32
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP02724
Comments Information
Function
- Has antibacterial activity. (By similarity)
Literature Information
- ·Literature 1
-
Title
- Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.
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Pubmed ID
- 16720578
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Reference
- J Biol Chem. 2006 Jul 21;281(29):19861-19871.
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Author
- Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A.