• DRAMP ID

    • DRAMP02727
    • Peptide Name

    • HmdSL-37 (cathelicidin; primates, mammals, animals)
    • Source

    • Hylobates sp. (Gibbon)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • SLGNFFRKARKKIGEEFKRIVQRIKDFLQHLIPRTEA
    • Sequence Length

    • 37
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal
    • Target Organism

    • In 20% TSB in SPB medium Escherichia coli (MIC=2 µM), Pseudomonas aeruginosa (MIC=8 µM), Staphylococcus aureus (MIC>32 µM), Enterococcus faecalis (MIC=8 µM).##In 20% SAB in SPB Candida albicans (MIC>32 µM). In 5% SAB in SPB Candida albicans (MIC=8 µM). In 20% SAB in PIL Candida albicans (MIC>32 µM).##In 5% TSB in SPB Escherichia coli (MIC=1 µM), Pseudomonas aeruginosa (MIC=2 µM), Staphylococcus aureus (MIC=2 µM).##In 20% TSB in PIL Escherichia coli (MIC>32 µM), Pseudomonas aeruginosa (MIC=16-32 µM); Staphylococcus aureus (MIC=8-16 µM), Enterococcus faecalis (MIC>32 µM).##In 50% MH in SPB medium Escherichia coli (MIC>32 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02727 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02727.
    • Formula

    • C204H334N62O51
    • Absent Amino Acids

    • CMWY
    • Common Amino Acids

    • KR
    • Mass

    • 4471.28
    • PI

    • 11
    • Basic Residues

    • 11
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 14
    • Net Charge

    • +7
    • Boman Index

    • -103.95
    • Hydrophobicity

    • -0.681
    • Aliphatic Index

    • 87.03
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 5

DRAMP02727

DRAMP02727 chydropathy plot
    • Function

    • Has antibacterial activity.
  • ·Literature 1
    • Title

    • Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.
    • Reference

    • J Biol Chem. 2006 Jul 21;281(29):19861-19871.
    • Author

    • Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A.