General Information
-
DRAMP ID
- DRAMP02730
-
Peptide Name
- Beta-defensin 104A (Defensin, beta 104; Defensin, beta 104A; primates, mammals, animals)
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Source
- Hylobates lar (Common gibbon) (White-handed gibbon)
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Family
- Belongs to the beta-defensin family
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Gene
- DEFB104A
-
Sequence
- EFEWDRICGYGTARCRNKCRSQEYRIGRCPNTFACCLRKWDESLLNSTKP
-
Sequence Length
- 50
-
UniProt Entry
- A4H204
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02730.
Physicochemical Information
-
Formula
- C254H396N80O75S6
Absent Amino Acids
- HMV
Common Amino Acids
- RC
Mass
- 5962.79
PI
- 8.91
Basic Residues
- 10
Acidic Residues
- 6
Hydrophobic Residues
- 11
Net Charge
- +4
-
Boman Index
- -160.08
Hydrophobicity
- -0.938
Aliphatic Index
- 43
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 14355
Absorbance 280nm
- 292.96
Polar Residues
- 20
DRAMP02730
Comments Information
Function
- Has antimicrobial activity (By similarity).
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Evolution and sequence variation of human beta-defensin genes.
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Pubmed ID
- PubMed ID is not available
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Reference
- Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
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Author
- Hollox EJ, Armour JAL.