• DRAMP ID

    • DRAMP02752
    • Peptide Name

    • Formaecin-2 (Pro-rich; ants, insects, animals)
    • Source

    • Myrmecia gulosa (Red bulldog ant)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GRPNPVNTKPTPYPRL
    • Sequence Length

    • 16
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • [Ref.9497332] Gram-negative bacteria: Escherichia coli NCTC 8196, Escherichia coli BLR.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Rich
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02752 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02752.
    • Formula

    • C81H131N25O22
    • Absent Amino Acids

    • ACDEFHIMQSW
    • Common Amino Acids

    • P
    • Mass

    • 1807.09
    • PI

    • 11
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 2
    • Net Charge

    • +3
    • Boman Index

    • -44.05
    • Hydrophobicity

    • -1.438
    • Aliphatic Index

    • 42.5
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 99.33
    • Polar Residues

    • 6

DRAMP02752

    • Function

    • Antibacterial activity against E.coli but none against other Gram-negative bacteria and Gram-positive bacteria.
    • Induction

    • By bacterial infection.
    • PTM

    • O-linked glycan consists of a Gal-GalNAc disaccharide, O-glycosylation is essential for full biological activity.
  • ·Literature 1
    • Title

    • Isolation from an ant Myrmecia gulosa of two inducible O-glycosylated proline-rich antibacterial peptides.
    • Reference

    • J Biol Chem. 1998 Mar 13;273(11):6139-6143.
    • Author

    • Mackintosh JA, Veal DA, Beattie AJ, Gooley AA.