General Information

    • DRAMP ID

    • DRAMP02752

    • Peptide Name

    • Formaecin-2 (Pro-rich; ants, insects, animals)

    • Source

    • Myrmecia gulosa (Red bulldog ant)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GRPNPVNTKPTPYPRL

    • Sequence Length

    • 16

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.9497332] Gram-negative bacteria: Escherichia coli NCTC 8196, Escherichia coli BLR.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02752 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02752.

Physicochemical Information

    • Formula

    • C81H131N25O22

    • Absent Amino Acids

    • ACDEFHIMQSW

    • Common Amino Acids

    • P

    • Mass

    • 1807.09

    • PI

    • 11

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +3

    • Boman Index

    • -44.05

    • Hydrophobicity

    • -1.438

    • Aliphatic Index

    • 42.5

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 99.33

    • Polar Residues

    • 6

DRAMP02752

Comments Information

    • Function

    • Antibacterial activity against E.coli but none against other Gram-negative bacteria and Gram-positive bacteria.

    • Induction

    • By bacterial infection.

    • PTM

    • O-linked glycan consists of a Gal-GalNAc disaccharide, O-glycosylation is essential for full biological activity.

Literature Information

  • ·Literature 1

    • Title

    • Isolation from an ant Myrmecia gulosa of two inducible O-glycosylated proline-rich antibacterial peptides.

    • Reference

    • J Biol Chem. 1998 Mar 13;273(11):6139-6143.

    • Author

    • Mackintosh JA, Veal DA, Beattie AJ, Gooley AA.