General Information

    • DRAMP ID

    • DRAMP02756

    • Peptide Name

    • Ponericin G4 (ants, insects, animals)

    • Source

    • Pachycondyla goeldii (Ponerine ant)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DFKDWMKTAGEWLKKKGPGILKAAMAAAT

    • Sequence Length

    • 29

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: B. cereus CIP 6624a, Bacillus megaterium ATCC 9885b, B.stearothermophilus CIP 675, B.stearothermophilus CIP 675, Bacillus subtilis ATCC 6623, Lactococcus lactis ssp. cremoris I116, Streptococcus pyogenes CIP 561, S. sanguinis CIP 55128, Micrococcus luteus CIP 5345;
      • Gram-negative bacteria: Klebsiella pneumoniae CIP 8291, Pseudomonas aeruginosa CIP A22, Saccharomyces cerevisae.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02756 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02756.

Physicochemical Information

    • Formula

    • C145H231N37O38S2

    • Absent Amino Acids

    • CHNQRSVY

    • Common Amino Acids

    • AK

    • Mass

    • 3164.77

    • PI

    • 9.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • -21.91

    • Hydrophobicity

    • -0.359

    • Aliphatic Index

    • 61.03

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 5

DRAMP02756

DRAMP02756 chydropathy plot

Comments Information

    • MOA

    • The comparison of ponericins with those well-studied peptides suggests that ponericins may adopt an amphipathic alpha-helical structure on cell membranes.

Literature Information

  • ·Literature 1

    • Title

    • Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii.

    • Reference

    • J. Biol. Chem. 2001; 276: 17823-17829.

    • Author

    • Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chafotte A, Dejean A, Rossier J.