General Information

    • DRAMP ID

    • DRAMP02756

    • Peptide Name

    • Ponericin G4 (ants, insects, animals)

    • Source

    • Pachycondyla goeldii (Ponerine ant)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DFKDWMKTAGEWLKKKGPGILKAAMAAAT

    • Sequence Length

    • 29

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria:
        Target OrganismActivity
        B. cereus CIP 6624a-
        Bacillus megaterium ATCC 9885b-
        B.stearothermophilus CIP 675-
        B.stearothermophilus CIP 675-
        Bacillus subtilis ATCC 6623-
        Lactococcus lactis ssp. cremoris I116-
        Streptococcus pyogenes CIP 561-
        S. sanguinis CIP 55128-
        Micrococcus luteus CIP 5345;-
      • Gram-negative bacteria:
        Target OrganismActivity
        Klebsiella pneumoniae CIP 8291-
        Pseudomonas aeruginosa CIP A22-
        Saccharomyces cerevisae-

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02756 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02756.

Physicochemical Information

    • Formula

    • C145H231N37O38S2

    • Absent Amino Acids

    • CHNQRSVY

    • Common Amino Acids

    • AK

    • Mass

    • 3164.77

    • PI

    • 9.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • -21.91

    • Hydrophobicity

    • -0.359

    • Aliphatic Index

    • 61.03

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 5

DRAMP02756

DRAMP02756 chydropathy plot

Comments Information

    • MOA

    • The comparison of ponericins with those well-studied peptides suggests that ponericins may adopt an amphipathic alpha-helical structure on cell membranes.

Literature Information

  • ·Literature 1

    • Title

    • Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii.

    • Reference

    • J. Biol. Chem. 2001; 276: 17823-17829.

    • Author

    • Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chafotte A, Dejean A, Rossier J.