General Information

    • DRAMP ID

    • DRAMP02758

    • Peptide Name

    • Ponericin G6 (ants, insects, animals)

    • Source

    • Pachycondyla goeldii (Ponerine ant)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLVDVLGKVGGLIKKLLP

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a, B. megaterium ATCC 9885b, B. stearothermophilus CIP 675, B. stearothermophilus CIP 675, B. subtilis ATCC 6623, Lactococcus lactis ssp. cremoris I116, Streptococcus pyogenes CIP 561, S. sanguinis CIP 55128, Listeria monocytogenes ATCC 15313, Micrococcus luteus CIP 5345, Staphylococcus aureus CIP 677, S. epidermidis CIP 53134;
      • Gram-negative bacteria: Klebsiella pneumoniae CIP 8291, Pseudomonas aeruginosa CIP A22, Saccharomyces cerevisiae LMA 720.

    • Hemolytic Activity

      • [Ref.11279030]Non-hemolytic activity against horse and sheep erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02758 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02758.

Physicochemical Information

    • Formula

    • C86H155N21O21

    • Absent Amino Acids

    • ACEFHMNQRSTWY

    • Common Amino Acids

    • L

    • Mass

    • 1819.3

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 20.03

    • Hydrophobicity

    • 0.983

    • Aliphatic Index

    • 178.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02758

DRAMP02758 chydropathy plot

Comments Information

    • Function

    • Has activity against Gram-positive bacteria and S. cerevisiae. Has non-hemolytic activity.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii.

    • Reference

    • J. Biol. Chem. 2001; 276: 17823-17829.

    • Author

    • Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chafotte A, Dejean A, Rossier J.