General Information

    • DRAMP ID

    • DRAMP02758

    • Peptide Name

    • Ponericin G6 (ants, insects, animals)

    • Source

    • Pachycondyla goeldii (Ponerine ant)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLVDVLGKVGGLIKKLLP

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.11279030]Gram-positive bacteria:
        Target OrganismActivity
        Bacillus cereus CIP 6624a-
        B. megaterium ATCC 9885b-
        B. stearothermophilus CIP 675-
        B. stearothermophilus CIP 675-
        B. subtilis ATCC 6623-
        Lactococcus lactis ssp. cremoris I116-
        Streptococcus pyogenes CIP 561-
        S. sanguinis CIP 55128-
        Listeria monocytogenes ATCC 15313-
        Micrococcus luteus CIP 5345-
        Staphylococcus aureus CIP 677-
        S. epidermidis CIP 53134;-
      • Gram-negative bacteria:
        Target OrganismActivity
        Klebsiella pneumoniae CIP 8291-
        Pseudomonas aeruginosa CIP A22-
        Saccharomyces cerevisiae LMA 720-

    • Hemolytic Activity

      • [Ref.11279030]Non-hemolytic activity against horse and sheep erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02758 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02758.

Physicochemical Information

    • Formula

    • C86H155N21O21

    • Absent Amino Acids

    • ACEFHMNQRSTWY

    • Common Amino Acids

    • L

    • Mass

    • 1819.3

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 20.03

    • Hydrophobicity

    • 0.983

    • Aliphatic Index

    • 178.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02758

DRAMP02758 chydropathy plot

Comments Information

    • Function

    • Has activity against Gram-positive bacteria and S. cerevisiae. Has non-hemolytic activity.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii.

    • Reference

    • J. Biol. Chem. 2001; 276: 17823-17829.

    • Author

    • Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chafotte A, Dejean A, Rossier J.