• DRAMP ID

    • DRAMP02765
    • Peptide Name

    • Ponericin-W4 (ants, insects, animals)
    • Source

    • Pachycondyla goeldii (Ponerine ant)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GIWGTALKWGVKLLPKLVGMAQTKKQ
    • Sequence Length

    • 26
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal, Antifungal
    • Target Organism

      • [Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 8.5mm), B. megaterium ATCC 9885b(Inhibition zone = 13.5mm), B. stearothermophilus CIP 675(Inhibition zone = 18mm), B. subtilis ATCC 6623(Inhibition zone = 13mm), Enterococcus faecalis CIP 636(Inhibition zone = 3mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 14mm), Streptococcus pyogenes CIP 561(Inhibition zone = 8mm), S. sanguinis CIP 55128(Inhibition zone = 7mm), Listeria ivanovii LMA 94d(Inhibition zone = 10mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 10mm), Micrococcus luteus CIP 5345(Inhibition zone = 12.5mm), Staphylococcus aureus CIP 677(Inhibition zone = 11.5mm), Staphylococcus aureus LMA(Inhibition zone = 13.5mm), S. epidermidis CIP 53134(Inhibition zone = 11.5mm);
      • Gram-negative bacteria: Escherichia coli(Inhibition zone = 8.5mm), Enterobacter cloacae CIP 6085(Inhibition zone = 16.5mm), Klebsiella pneumoniae CIP 8291(Inhibition zone = 9mm), Proteus mirabilis LMA TP(no detected), Salmonella enterica CIP 813(no detected), Serratia marcescens LMA TP(Inhibition zone = 13mm), Flavobacterium meningosepticum CIP 6057(no detected), Pseudomonas aeruginosa CIP A22(Inhibition zone = 17mm).
    • Hemolytic Activity

      • [Ref.11279030]2mm in test condition against horse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 μl of the peptide solution and placed overnight at 4℃ to allow the diffusion of the hemolytic agent)
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Serum or Protease Type

    • Not available
    • Stability Data

    • Not available
    • Assay

    • Not available
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02765 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02765.
    • Formula

    • C134H223N35O31S
    • Absent Amino Acids

    • CDEFHNRSY
    • Common Amino Acids

    • K
    • Mass

    • 2852.52
    • PI

    • 10.6
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +5
    • Boman Index

    • 3.1
    • Hydrophobicity

    • 0.027
    • Aliphatic Index

    • 105
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 11000
    • Absorbance 280nm

    • 440
    • Polar Residues

    • 6

DRAMP02765

DRAMP02765 chydropathy plot
    • Function

    • Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities.
    • Tissue specificity

    • Expressed by the venom gland.
  • ·Literature 1
    • Title

    • Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii.
    • Reference

    • J. Biol. Chem. 2001; 276: 17823-17829.
    • Author

    • Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J.