• • DRAMP ID

  • DRAMP02766

• • Peptide Name

  • Ponericin-W5 (ants, insects, animals)

• • Source

  • Pachycondyla goeldii (Ponerine ant)

• • Family

  • Belongs to the ponericin-W family

• • Gene

  • Not found

• • Sequence

  • FWGALIKGAAKLIPSVVGLFKKKQ

• • Sequence Length

  • 24

• • UniProt Entry

  • P82427

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal, Antifungal

• • Target Organism

  • • [Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 7mm), B. megaterium ATCC 9885b(Inhibition zone = 12mm), B. stearothermophilus CIP 675(Inhibition zone = 17mm), B. subtilis ATCC 6623(Inhibition zone = 13mm), Enterococcus faecalis CIP 636(Inhibition zone = 3mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 11mm), Streptococcus pyogenes CIP 561(Inhibition zone = 6.5mm), S. sanguinis CIP 55128(Inhibition zone = 4.5mm), Listeria ivanovii LMA 94d(Inhibition zone = 8mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 6.5mm), Micrococcus luteus CIP 5345(Inhibition zone = 11mm), Staphylococcus aureus CIP 677(Inhibition zone = 7.5mm), Staphylococcus aureus LMA(Inhibition zone = 9mm), S. epidermidis CIP 53134(Inhibition zone = 7.5mm);
    • Gram-negative bacteria: Escherichia coli(Inhibition zone = 3mm), Enterobacter cloacae CIP 6085(Inhibition zone = 11mm), Klebsiella pneumoniae CIP 8291(Inhibition zone = 6.5mm), Proteus mirabilis LMA TP(no detected), Salmonella enterica CIP 813(no detected), Serratia marcescens LMA TP(Inhibition zone = 11mm), Flavobacterium meningosepticum CIP 6057(Inhibition zone = 5mm), Pseudomonas aeruginosa CIP A22(Inhibition zone = 14mm).

• • Hemolytic Activity

  • • [Ref.11279030]4mm in test condition against horse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 μl of the peptide solution and placed overnight at 4℃ to allow the diffusion of the hemolytic agent)

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP02766.

DRAMP02766

• • Function

  • Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities.

• • Tissue specificity

  • Expressed by the venom gland.

• ·Literature 1

• • Title

  • Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii.

• • Pubmed ID

  • 11279030

• • Reference

  • J. Biol. Chem. 2001; 276: 17823-17829.

• • Author

  • Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J.